Kabul was a bridge between Indian Mughal Empire and Central Asia, the ancestral homeland of the founder of the Mughal Empire.Kabul, the capital of Afghanistan, carries about 3,500 years old historical records mentioning Kabul with different names like, Kubha, Gandahara, Kabura, Ortospana, Kapul, Zavul, and Zabul etc.Many great warriors and conquero
Cancer cells within tumor masses are chronically exposed to stress caused by nutrient deprivation, oxygen limitation, and high metabolic demand.They also accumulate hundreds of mutations, potentially generating aberrant proteins that can induce proteotoxic stress.Finally, cancer cells are exposed to various damages during chemotherapy.In a growing
Hypoxia switches the metabolism of tumor cells and induces drug resistance.Currently, no therapeutic exists that effectively and specifically targets hypoxic cells in tumors.Development of such therapeutics critically depends on the availability of in vitro models that accurately recapitulate hypoxia as found in the tumor microenvironment.Here, we